74 years old, married, fully autonomous in daily activities. Her complaints are fatigue and dyspnea with medium exertion, that limit her daily activities significantly; She also reports episodes of paroxysmal nocturnal dyspnea, orthopnea, increased waist circumference and bilateral lower limb edema of afternoon predominance.

Novartis Netherlands

Anne Mary

Internal medicine 

HF Clinical Case - Ms. Anne Mary [English]

68 years old male, autonomous in activities of daily living, diagnosed with HFrEF (EF 28% in transthoracic echocardiogram of this hospitalization). Committed to the hospital for decompensated HF in the context of a community-acquired right base pneumonia. Currently with only little congestion; hospital discharge is expected quickly. 

Bruno Abbey

HF Clinical Case - Mr. Bruno [English]

Male patient, fully autonomous in daily activities. He is being accompanied in the heart clinic since the beginning of the year due to ischemic heart failure.

This action is correct. According to PARADIGM-HF (2016), comparing to enalapril, sacubitril-valsartan was associated to:
- 20% reduction of the risk of cardiovascular death;
- 21% reduction of the risk of first hospitalization due to heart failure decompensation;
- 16% reduction of all cause mortality; 
- reduction of symptoms and NYHA class.