may 2020 • Immunity

Immunology of COVID-19: current state of the science

Vabret N. , Britton G.J., Gruber C., et al.

DOI: 10.1016/j.immuni.2020.05.002

Content curation::David Rodrigues

Key message

Revisão narrativa do estado atual do conhecimento das respostas imunes inatas e adaptativas suscitadas pela infecção por SARS-CoV-2 e as vias imunológicas que provavelmente contribuem para a gravidade e morte da doença. Também se discute o rational e o resultado clínico das estratégias terapêuticas atuais, bem como de ensaios clínicos prospectivos para prevenir ou tratar a infecção por SARS-CoV-2.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.