march, 2020

Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China

Dong Y, Mo X, Hu Y, et al.

DOI: 10.1542/peds.2020-0702

Pediatrics

Abstract

OBJECTIVES: To identify the epidemiological characteristics and transmission patterns ofpediatric patients with COVID-19 in China.METHODS: Nationwide case series of 2143 pediatric patients with COVID-19 reported to theChinese Center for Disease Control and Prevention from January 16 to February 8, 2020 wereincluded. The epidemic curves were constructed by key dates of disease onset and case diagnosis.Onset-to-diagnosis curves were constructed by fitting a log-normal distribution to data on bothonset and diagnosis dates.RESULTS: There were 731 (34.1%) laboratory-confirmed cases and 1412 (65.9%) suspectedcases. The median age of all patients was 7 years (interquartile range: 2-13), and 1213 cases(56.6%) were boys. Over 90% of all patients were asymptomatic, mild, or moderate cases. Themedian time from illness onset to diagnoses was 2 days (range: 0 to 42 days). There was a rapidincrease of disease at the early stage of the epidemic and then there was a gradual and steadydecrease. Disease rapidly spread from Hubei Province to surrounding provinces over time. Morechildren were infected in Hubei province than any other province.CONCLUSIONS: Children at all ages appeared susceptible to COVID-19, and there was nosignificant gender difference. Although clinical manifestations of children’s COVID-19 caseswere generally less severe than those of adults’ patients, young children, particularly infants, werevulnerable to infection. The distribution of children’s COVID-19 cases varied with time and space,and most of the cases concentrated in Hubei province and surrounding