january 2020 • New England Journal of Medicine

Venous Thrombosis during Spaceflight

Auñón-Chancellor, Serena M., Pattarini, James M., Moll, Stephan, Sargsyan, Ashot

DOI: 10.1056/NEJMc1905875


An obstructive jugular-vein thrombosis developed in an astronaut 2 months into a 6-month space mission, a clinical scenario with no evidence base to support the choice of a management approach. The thrombosis was managed with enoxaparin, followed by apixaban, which was discontinued 4 days before Earth landing. No adverse sequelae were noted.